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Biosensis/Rat Interleukin 10 ELISA Kit (1 plate)/BEK-2047-1P/1 Ea
用于BEK-2211和类似ELISA分析的Biosensis/分泌型IgA阻滞剂/BL-001-1250/1250µg
Biosensis/兔抗人BNIP3（38-53）多克隆抗体：亲和纯化/R-1597-100/100µg
Biosensis/Mouse monoclonal antibody to human copine 6 [6D11]: IgG/M-816-100/100 µg
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Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
来自 : 发布时间：2024-05-16
Description TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer.
Batch No. See product label
Unit size 100 µl
Antigen Extracellular domain of glycosylated human TrkA protein produced in mammalian cells was used as the immunogen.
Other Names Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK;
Accession NTRK1_HUMAN
Produced in Rabbit
Purity Whole serum
Applications IHC (1:1000 dilution), Western Blotting (denaturing and non-reducing SDS-PAGE, 1:1000-1:2500 dilution), 1-site ELISA (1:5000 dilution). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity Specificity was demonstrated by immunohistochemistry. When used for immunohistochemistry in rat dorsal root ganglia, staining is restricted to the known distribution of TrkA, that is in small, nociceptive neurons.
Cross-reactivity Reacts with human, rat and mouse TrkA. Other species not yet tested.
Form Lyophilised
Reconstitution Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Specific References Kobayashi K et al. (2015) Nerve Growth Factor Signals as Possible Pathogenic Biomarkers for Perineural Invasion in Adenoid Cystic Carcinom. Otolaryngol Head Neck Surg. 2015 Aug;153(2):218-24. Species: Human. Application: IHC.Uren RT et al. (2014) A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology. J Neurochem. 2014 May;129(4):614-27. Species: Mouse. Application: IF.
References 1. Zhang FX, et al. (2005) Brain Res 16; 1062 (1-2) pp. 92-100.2. Gearhart DA, et al. (2006) J Neurosci Methods. 150(2) pp. 159-173.

本文链接： http://biosensis.immuno-online.com/view-1466311053.html

发布于 ： 2024-05-16 阅读（）
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公司介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
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TR-200-BG型 PE-1243-50型 抗体试剂盒 PE-1246-5型 TR-100-BG型 S-1754-500型 神经营养因子 糖尿病与肥胖 细胞内贩运
电话：PE-1239-5 神经肽和受体 B-100-PS型 受体和通道分子 2个平板ELISA试剂盒 M-1763-100英尺 TR-200-BGT公司 电话：PE-1239-2 PE-1242-5型 M-1249-100号 神经营养因子受体 细胞周期调节器 S-1759-100号 PE-1606-100型 PE-1762-100型 B-200-PS型 PE-019-100型 PE-1241-5型 PE-003-100 1个平板ELISA试剂盒 BL-003-1000型 PE-1246-2型 感觉神经系统 PE-1253-100型 TR-100-FJ BL-005-500型 神经内分泌 M-1728-100型 DNA损伤与修复 PE-001-100型 PE-1608-1型 TR-400-AG公司 PE-1243-25 细胞标记 PE-1608-5型 TR-100-FJT 自噬 PE-1242-2型 其他神经元 神经递质和酶 抗氧化酶 神经元标志物 标记抗体 BL-004-500型 PE-019-25 PE-1608-10型 BL-002-1250型 受体体嵌合体 信令与转录 基质和粘附分子 BL-001-1250型 癌症 PE-019-500 干细胞 连接蛋白 TR-300-AG型 细胞凋亡 PE-1252-100型 生长因子 发展 阿尔茨海默氏症/帕金森氏症
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